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        Menotrophin
        CAS No.: 9002-68-0 (Gonadotrophin; Treatment of infertility)

        Short Description:

        Source: Extracted from the urine of healthy pregnant women
        Function and use: For women, it can promote the maturation and ovulation of follicles, and maintain the function of the corpus luteum. For men, it can stimulate the development of Leydig cells, increase androgen secretion, promote testicular descent and the development of male secondary sexual characteristics. Combined with urinary gonadotropin, it can simulate the physiological peak of luteinizing hormone and induce ovulation. Clinically, chorionic gonadotropin is still the drug of choice for the treatment of menstrual disorders, anovulatory infertility, threatened abortion and habitual live birth, cryptorchidism, and male sexual dysfunction.

        Menotrophin-Pharmacopoeia?Standard:?BP


        Product Detail

        Product Tags

        CAS No.: 61489-71-2
        Complies with CP2020,, BP2023

        Specification

        Menotrophin

        Source

        Menopausal woman urine

        Process description

        Menotrophin obtained from the urine of post-menopausal women, mainly contain follicle-stimulating hormone and luteinizing hormone.

        Manufacturing requirements

        This product should be extracted from healthy human urine. The production process should conform with the requirements of current version of Good Manufacturing Practice. It needs to undergo appropriate technological methods for virus safety control during the production process, so that any viruses such as hepatitis virus, human immunodeficiency virus, etc. can be removed or inactivated.

        Pharnacopoeia standard

        CP

        BP

        Character

        An almost white to slightly yellow powder.

        Soluble in water.

        An almost white or slightly yellow powder.

        Soluble in water

        Identification

        Causes enlargement of the ovaries of immature female rats and increases the weight of the seminal vesicles and prostate gland of immature male rats when administered as directed in the Assay. Causes enlargement of the ovaries of immature female rats and increases the weight of the seminal vesicles and prostate gland of immature male rats when administered as directed in the Assay.

        Test

        Residual

        Solvent(ethanol)

        Not more than 0.5%

        _________

        Water

        Not more than 5.0%

        Not more than 5.0%

        Abnormal toxicity

        All the animals survive for 48 hours.

        _________

        Bacterial endotoxin

        Not more than 1.0EU per IU FSH.

        Not more than 0.78 EU per IU FSH.

        Potency

        FSH

        Not less than 400IU/mg

        Not less than 40 IU/mg

        LH/FSH

        Approximately 1

        Approximately 1

        Microbial limit

        TAMC

        ≤103 CFU/g

        _________

        TYMC

        ≤102 CFU/g

        _________

        Escherichia coli

        Should not be detected

        _________

        Virus

        Hbs Ag

        Should be negative

        _________

        Storage

        Store in an airtight container, protected from light, at a temperature not exceeding 10°C.

        Kept in an airtight, tamper-evident container and protected from light.

        Category

        Gonadotropin drugs

        Preparation

        Menotrophin for injection

        Indications

        1.Use in combination with chorionic gonadotropin or clomiphene to treat anovulatory infertility. It can be used in anovulatory patients with insufficient pituitary gonadotropin secretion or hypothalamic gonadotropin-releasing hormone secretion, and is currently generally advocated for cases where ovulation induction is ineffective, such as clomiphene or bromocriptine. Combined with clomiphene, it can reduce the dosage of this product by about 50%, and at the same time can reduce the incidence of ovarian hyperstimulation.

        2.It is also used for primary or secondary amenorrhea, male sperm deficiency and ovarian function tests.


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