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        Kallidinogenase
        CAS No.: 9001-01-8 (kinin-releasing activity)

        Short Description:

        Source: Extracted from porcine pancreas
        Function and use:Kallidinogenase is a kind of kallikrein in human tissues and mammals. It exists in the body in the form of an inactive precursor—prekallikrein, which can degrade kininogen into kinin. Kinin can dilate blood vessels and capillaries,increase vascular permeability,improve microcirculation, regulate blood pressure, and reduce myocardial oxygen consumption. This enzyme is also an activating factor, which can activate plasminogen into plasmin, hydrolyze insoluble fibrin into soluble small peptides, thereby leading to thrombolysis, and can also regulate and reduce hypertension. For a variety of heart and cerebrovascular diseases, such as essential hypertension, arteriosclerosis, coronary atherosclerotic heart disease, cerebral arteriosclerosis, cerebral thrombosis, retinal blood supply disorders and peripheral vascular disease.

        Kallidinogenase-Pharmacopoeia?Standard:?JP


        Product Detail

        Product Tags

        CAS No.: 9001-01-8
        Complies with CP2020,?JP18

        Specification

        Kallidinogenase

        Source

        Porcine pancreas

        Process description

        Kallidinogenase is an enzyme extracted from healthy porcine pancreas, and has kinin-releasing activity based on cleavage of kininogen.

        Production

        requirements

        This product should be extracted from porcine pancreas that has passed quarantine. Production process should conform with the requirements of current version of Good Manufacturing Practice. This product is derived from animals, and appropriate virus inactivation processes should be used for virus safety control during production

        Pharmacopoeia standard

        CP

        JP

        for oral

        for injection

        Character

        White or almost white powder. Odorless.

        It is freely soluble in water, and practically insoluble in ethanol and diethyl ether.

        A white to light brown powder. It is odorless or has a faint, characteristic odor.It is freely soluble in water, and practically insoluble in ethanol (95) and in diethyl ether.

        Identification

        The value of R should be 0.12~0.17

        The value of I does not exceed 0.2

        The retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution

        the value of R is between 0.12 and 0.16

        Test

        pH

        5.5-7.5

        5.5-7.5

        Appearance of solution

        _______

        Should be clear

        _______

        Purity

        ≥75%

        ≥90%

        _______

        Purity

        Fat

        The mass of residue is not more than 5mg

        The mass of residue is not more than 1mg

        Kininase

        _______

        The value R is not less than 0.8

        Trypsin-like substance

        _______

        The value of T does not exceed 0.05

        Protease

        A280≤0.2

        The value of (A-A0) not more than 0.2

        Loss on drying

        Not more than 5.0%

        Not more than 2.0%

        Residue on ignition

        Not more than 3.0%

        Not more than 3%

        Bacterial endotoxin

        _______

        ≤2.5 EU/IU

        _______

        Kinin-releasing activity

        _______

        Not less than 500ng bradykinin equivalent/minute/unit

        Potency

        Activity

        _______

        Not less than 25IU/mg

        Specific activity

        ≥300IU/mg.pr

        ≥ 600IU/mg.pr

        Not less than 100IU/mg.pr

        Microbial limit

        TAMC

        ≤103cfu/g

        _______

        TYMC

        ≤102cfu/g

        _______

        Escherichia coli

        Should not be detected per g

        _______

        Salmonella

        Should not be detected per 10g

        _______

        Storage

        Store in an airtight container, protected from

        ?light of temperature below 20℃

        Tight containers

        Category

        Vasodilators.

        Preparation

        Kallidinogenase enteric-coated tablets

        Indications

        It can be used for a variety of cardiac and cerebrovascular lesions, such as essential hypertension, arteriosclerosis, coronary atherosclerotic heart disease, cerebral arteriosclerosis, cerebral thrombosis, retinal blood supply disorders and peripheral vascular lesions. Recent studies have found that this product can be used to prevent diabetic microangiopathy and early diabetic nephropathy (has a good therapeutic effect and can reduce the amount of urine albumin excreted).


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